@article{APS7873,
author = {Jin-chuan YAN and Zong-gui WU and Xian-tao KONG and Ren-qian ZONG and Lin-zen ZHAN},
title = {Relation between upregulation of CD40 system and complex stenosis morphology in patients with acute coronary syndrome},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM:
To investigate whether upregulation of CD40-CD40 ligand system is related to matrix metalloproteinases level and stability of coronary atherosclerotic plaque in patients with acute coronary syndrome (ACS).
METHODS:
Sixteen normal controls and 56 patients including 24 with stable angina (SA), 20 with unstable angina (UA), and 12 with acute myocardial infarction (AMI) were investigated. The expression of CD40 and CD40L on platelet was analyzed by flow cytometry. Serum soluble CD40L (sCD40L), MMP-9 and MMP-3 level was determined by ELISA. All coronary stenosis with > or =30% diameter reduction were assessed by angiographic coronary stenosis morphology.
RESULTS:
Patients with ACS showed a significant increase of CD40 (75 +/- 12 MIF) and CD40L (13 +/- 4 MIF) coexpression on platelets compared with control and SA group (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7873}
}