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Effects of Ginkgolide B on action potential and calcium, potassium current in guinea pig ventricular myocytes

   
@article{APS7863,
	author = {Xiao-yan QI and Zhi-xiong ZHANG and You-qiu XU},
	title = {Effects of Ginkgolide B on action potential and calcium, potassium current in guinea pig ventricular myocytes},
	journal = {Acta Pharmacologica Sinica},
	volume = {25},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To investigate the effect of Ginkgolide B (GB) on action potential (AP), delayed rectifier potassium current (IK), and L-type calcium current (I(Ca-L)) in guinea pig ventricular myocytes.
METHODS:
Single ventricular myocytes were isolated by an enzymatic dissociation method. AP, IK, I(Ca-L) were recorded by whole-cell patch-clamp technique in either current or voltage clamp mode.
RESULTS:
GB shortened APD in a concentration-dependent manner. GB 0.1, 1, and 10 micromol/L shortened APD50 by 7.9% (n=5, P>0.05), 18.4% (n=5, P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7863}
}