@article{APS7859,
author = {Wei ZHANG and Hong-wei JIN and Xiao-liang WANG},
title = {Effects of presenilins and beta-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM:
To study the effects of presenilin-1 (PS-1), presenilin-2 (PS-2), and amyloid beta-protein precursor (APP695) on delayed rectifier potassium channels (IK) in the cultured rat hippocampal neurons.
METHODS:
PS-1, PS-2, and APP695 were transfected into the cultured rat hippocampal neurons by transient transfection techniques. The IK current was observed by the whole cell patch-clamp techniques.
RESULTS:
IK was increased in cultured rat hippocampal neurons, after transient transfection of PS-1, PS-2, and APP695. IK amplitudes and densities were significantly increased from (1689 +/- 412) pA, (48 +/- 18) pA/pF (mock cells, GFP alone, n=17) to (5565 +/- 1403) pA, (252 +/- 107) pA/pF (PS-1/GFP, n=22, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7859}
}