@article{APS7829,
author = {Bing MA and Yang XIANG and Tao LI and He-ming YU and Xue-jun LI},
title = {Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel},
journal = {Acta Pharmacologica Sinica},
volume = {25},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM:
To study the effect of topiramate on tumor metastasis and its relation with aquaporin 1 (AQP1) water channel.
METHODS:
Lewis lung carcinoma metastatic model was used to determine the effect of topiramate on tumor growth and metastasis. Colorimetric estimation was used to investigate the action of topiramate on carbonic anhydrase (CA) activity. Western blotting and immunohistochemical analysis were used to study the influence of topiramate on AQP1 water channel expression in lungs or tumor tissues of mice bearing Lewis lung carcinoma.
RESULTS:
Treatment with topiramate (120 mg/kg/d, ig for 20 d) reduced the growth of primary tumor significantly (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7829}
}