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Effects of allitridi on intracellular Ca2+ concentration in isolated rat brain cells

   
@article{APS7807,
	author = {Xiao-hong Ma and Xin-xin Pan and Tian-pei Liu},
	title = {Effects of allitridi on intracellular Ca2+ concentration in isolated rat brain cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {7},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study actions of allitridi extracted from garlic on intracellular calcium in isolated rat brain cells.
METHODS: Brain cells were isolated from newborn rat brain with Fura 2-AM measurements of intracellular Ca2+ concentration ([Ca2+]i).
RESULTS: Allitridi 1-100 mumol.L-1 concentration-dependently blocked increases of [Ca2+]i caused by potassium chloride and sodium glutamate (Glu) with IC50 of 59.7 and 69.9 mumol.L-1 respectively. Allitridi 100 mumol.L-1 blocked norepinephrine (Nor)-induced [Ca2+]i elevation.
CONCLUSION: Allitridi is an effective agent for blocking the [Ca2+]i increase caused by potassium chloride, Nor and Glu.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7807}
}