@article{APS7798,
author = {Xiao-yan Li and Chong-bin Zhu and Hai-nan Chen and Yan-hua Zhu and Gen-cheng Wu and Shao-fen Xu},
title = {Effects of fenfluramine combined with electroacupuncture on monoamine release in periaqueductal gray of rat brain},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {7},
year = {2016},
keywords = {},
abstract = {AIM: To study the changes of monoamines in ventrolatoral periaqueductal gray of rat brain before and after electroacupuncture (EA) analgesia (EAA) was enhanced by fenfluramine (Fen), a 5-hydroxytryptamine (5-HT) releaser.
METHODS: Monoamines were collected by in vivo microdialysis and measured by HPLC connected with electrochemical detector.
RESULTS: The level of norepinephrine (Nor) after EA was decreased (P < 0.05 vs NS group). The contents of 5-HT, 5-hydroxyindol acetic acid (5-HIAA), dopamine (DA), and homovanillic acid (HVA) in periaqueductal gray dialysate were increased (P < 0.05 vs NS group). When Fen was combined with EA, the level of 5-HT and 5-HIAA were further increased (P < 0.05 vs NS + EA group). There was no obvious change of Nor, DA, and HVA.
CONCLUSION: Fen potentiating EAA may be related to further activation of serotoninergic system.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7798}
}