@article{APS7796,
author = {Zheng-Hong Li and Li-Dong Shan and Xing-Hong Jiang and Shi-Yu Guo and Guang-Di Yu and Tadashi Hisamitsu and Qi-Zhang Yin},
title = {Analgesic effect of endomorphin-1},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {11},
year = {2016},
keywords = {},
abstract = {Aim: To study the analgesic effect of endomorphin-1 (EM-1).
Methods: The experiment was performed in rats and mice to study the analgesic effect of intraperitoneal (ip) injection of EM-1 with tail stimulation-vocalization test, writhing test, adjuvant arthritis, and neuropathic pain model and to compare it with the analgesic effects produced by intracerebroventricular (icv) and intrathecal (it) administrations.
Results: 1) EM-1 raised the pain threshold dose-dependently in tail stimulation-vocalization test in rats and inhibited the writhing responses induced by ip acetic acid in mice. EM-1 also decreased the hyperalgesia in both adjuvant arthritis and neuropathic pain model. 2) The analgesic effect induced by central (icv and it) administration of EM-1 was faster and more powerful than that induced by peripheral (ip) administration. 3) The analgesic effect of EM-1 was reversed by naloxone (opioid receptor antagonist), as well as by cyprodime (mu-opioid receptor selective antagonist). Repeated administrations of EM-1 induced tolerance.
Conclusion: EM-1 had a definite analgesic effect and the analgesic effect of EM-1 was mediated by central mu-opioid receptor.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7796}
}