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Dauricine inhibits redistribution of platelet membrane glycoprotein IV and release of intracellular alpha-granule thrombospondin induced by thrombin

   
@article{APS7779,
	author = {Tao Guo and Yan-zhou Zhang and Dong-xu Liu and Ping Zou and Di Shen},
	title = {Dauricine inhibits redistribution of platelet membrane glycoprotein IV and release of intracellular alpha-granule thrombospondin induced by thrombin},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the possibility of dauricine (Dau) inhibiting redistribution of platelet membrane glycoprotein IV (GPIV) and release of intracellular alpha-granule thrombospondin (TSP) on platelet activation.
METHODS:
Using the flow cytometric assay of washed platelet to record expression of GPIV and release of TSP induced by thrombin.
RESULTS:
Dau did not affect GPIV and TSP on resting platelet membrane but inhibited redistribution of GPIV to the platelet surface and TSP release on activated platelet. There was a marked positive correlation between changes of GPIV and TSP (r = 0.511, P < 0.01). The inhibitory effect of Dau appeared not to be Ca2+ concentration-dependent.
CONCLUSION:
Dau inhibited redistribution of GPIV and release of intracellular alpha-granule thrombospondin induced by thrombin.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7779}
}