@article{APS7763,
author = {Cai-Ping MAO and Mei-Lin XIE and Zhen-Lun GU},
title = {Effects of konjac extract on insulin sensitivity in high fat diet rats.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {9},
year = {2016},
keywords = {},
abstract = {AIM: To evaluate the effects of konjac extract (KE) on insulin sensitivity in
insulin resistance (IR) rats induced by high fat diet (HFD).
METHODS: Wistar rats were fed on HFD for 4 weeks, then treated with KE 1.5, 3.0
g/kg/d and metformin (Met) 0.1 g/kg/d for 4 weeks, respectively. The effects of
KE on intake of food and drink, body weight, and excretion were investigated.
Serum insulin was measured by double-radioimmunoassay. Blood glucose, total
cholesterol (TC), triglycerides (TG), and high-density lipoprotein-cholesterol
(HDL-C) were measured by enzyme methods, respectively. Low-density
lipoprotein-cholesterol (LDL-C) was calculated. Tissue glycogen was determined by
modified anthracene ketone method and tissue TG by glycerin phosphor sour
oxidation enzyme method. Insulin sensitivity was measured by modified
glucose-insulin tolerance test (K value).
RESULTS: HFD caused IR after 4 weeks (K value: 5.2+/-0.9 vs 8.3+/-0.7, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7763}
}