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E-4031 enhanced Ca2+ transient and ventricular myocytes contraction via reverse mode Na+/Ca2+ exchange in normal and hypertrophic rats.

   
@article{APS7751,
	author = {Xiang-Li CUI and Lu-Ying ZHAO and Bo-Wei WU},
	title = {E-4031 enhanced Ca2+ transient and ventricular myocytes contraction via reverse mode Na+/Ca2+ exchange in normal and hypertrophic rats.},
	journal = {Acta Pharmacologica Sinica},
	volume = {23},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effects of
N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesul
fonamide dihydrochloride dihydrate (E-4031), a specific Ik blocker, on Ca2+
transient and cell contraction of normal and hypertrophied rat ventricular
myocytes.
METHODS: Electrically triggered Ca2+ transient and cell shortening were measured 
simultaneously using the Ion Imaging System with charge coupled digital (CCD)
camera.
RESULTS: E-4031 (10 micromol/L) increased Ca2+ transient and cell shortening from
(210+/-49) and (3.0+/-0.8) micron to (245+/-47) and (3.6+/-1.0) micron,
respectively (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7751}
}