@article{APS7725,
author = {Jun-Li CAO and Hai-Lei DING and Li-Cai ZHANG and Shi-Ming DUAN and Yin-Ming ZENG},
title = {Pretreatment with midazolam suppresses morphine withdrawal response in mice and rats.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {8},
year = {2016},
keywords = {},
abstract = {AIM: To investigate the roles of pretreatment with midazolam on morphine
withdrawal in mice and rats.
METHODS: Acute and chronic morphine dependence and naloxone-precipitated
withdrawal models were employed in the present study. Cyclic adenosine
monophosphate (AMP) content and Fos protein expression were measured by
radioimmunoassay and immunocytochemistry, respectively.
RESULTS: Coadministration of midazolam (2 mg/kg, ip) and morphine prevented the
development of both acute and chronic morphine dependence in mice. Compared to
saline-morphine group (3.0, 95 % confidence limits: 1.9-4.3 mg/kg), ED50 of
naloxone-precipitated withdrawal jumping increased significantly in
midazolam-morphine group (10.4, 95 % confidence limits: 8.5-12.3 mg/kg) in acute
morphine-dependent mice (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7725}
}