@article{APS7713,
author = {Ke-Qin ZHANG and Jia-Wei CHEN and Qing-Nan LI and Guang-Fu LI and Xiao-Yun TIAN and Lian-Fang HUANG and Li-Hua BAO and Mei-Lian WANG},
title = {Effect of intermittent injection of recombinant human parathyroid hormone on bone histomorphometry of ovariectomized rats.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {7},
year = {2016},
keywords = {},
abstract = {AIM: To observe the effect of intermittent parathyroid hormone (PTH)
administration on bone histomorphology of relatively old ovariectomized rats.
METHODS: The 6-month-old female SD rats were randomly divided into 5 groups: (1)
sham-operated for baseline (ShamB, n=5), (2)ovariectomized for baseline (OVXB,
n=6), (3) Sham-operated for end point (ShamE, n=6), (4) ovariectomized for end
point (OVXE, n=6), (5) ovariectomized for PTH treatment (OVXEP, n=6). ShamB and
OVXB rats were sacrificed 3 months after operation, ShamE, OVXE and OVXEP rats
were sacrificed 4.5 months after operation. During 3-4.5 months after operation,
OVXEP rats received daily subcutaneous injection of rhPTH1-84, while ShamE and
OVXE received vehicle injection. The proximal tibiae of all rats were processed
without decalcification for quantitative bone histomorphometry.
RESULTS: The percent trabecular area (TbAr) of OVXEP was significantly greater
than that of OVXE (P 0.05), but was
smaller than that of ShamE (P },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7713}
}