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Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products

   
@article{APS7702,
	author = {Bin Zhou and Jun-ping Zhang and Zhen-lin Hu and Ye-xiong Tan and Ding-hua Qian},
	title = {Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the effect of fibrin fibrinogen degradation products (FFDP) on release of interleukin-1 (IL-1) and interleukin-6 (IL-6) from mouse peritoneal macrophages, and the effect of a new selectively potent protein kinase C inhibitor Ro 31-8220 (Ro).
METHODS:
IL-1 and IL-6 activities were measured by thymocyte proliferation assay and B9 cell proliferation methyl thiazolyl tetrazolium (MTT) colorimetric method, respectively.
RESULTS:
Ro 0.01-1 mumol.L-1 obviously inhibited FFDP-induced release of IL-1 and IL-6 from mouse peritoneal macrophages.
CONCLUSION:
Ro exerted inhibitory effects on FFDP-induced release of IL-1 and IL-6 in vitro.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7702}
}