@article{APS7676,
author = {George C Y Chiou and Shirley X L Liu},
title = {Systemic anti-inflammation by synthetic interleukin-1 blockers},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM:
To study the systemic anti-inflammatory actions of interleukin-1 (IL-1) blockers, OB-101 and OB-186.
METHODS:
Prevention of palm swelling induced by carrageenin injection was used as an animal model of systemic anti-inflammation efficacy.
RESULTS:
Both OB-101 and OB-186 (10-30 mg.kg-1) were approximately 10-30-fold more potent than aspirin (300 mg.kg-1) to inhibit carrageenin-induced systemic inflammation. The LD50 of OB-101 and OB-186 were at least 20 g.kg-1 i.g., indicating that they were extremely safe agents with a therapeutic index (LD50/ED50) of at least 2000.
CONCLUSION:
These IL-1 blockers are extremely safe systemically and are useable for the treatment of systemic inflammation such as rheumatoid arthritis.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7676}
}