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Dihydroetorphine-induced place preference was mediated by dopamine D1 receptors in rats.

   
@article{APS7670,
	author = {Zhong-hua Liu and Kai-gao Zhang},
	title = {Dihydroetorphine-induced place preference was mediated by dopamine D1 receptors in rats.},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the influence of dopamine (DA) receptor antagonists upon the rewarding property of dihydroetorphine (DHE).
METHODS:
Conditioned place preference (CPP) paradigm was used to characterize the rewarding effect of DHE. DA receptor antagonists were injected administered subcutaneously or peritoneally and microinjected into nucleus accumbens (NAcc).
RESULTS:
DHE (0.05, 0.5, and 5.0 micrograms.kg-1, s.c.) produced place preference (P < 0.01). Both the DA receptor antagonist haloperidol and the selective D1 receptor antagonist Sch-23390 attenuated the place preference produced by DHE (0.5 microgram.kg-1, s.c.). l-Sulpiride and spiperone, selective D2 receptor antagonists, had no such effects.
CONCLUSION:
The D1 (but not D2) receptors in NAcc are crucial in the mediation of the rewarding effect of DHE.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7670}
}