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Pharmacokinetics of atenolol enantiomers in 12 Chinese healthy men.

   
@article{APS7666,
	author = {Xiao-mei Wang and Xi-yong Yu and Shu-guang Lin},
	title = {Pharmacokinetics of atenolol enantiomers in 12 Chinese healthy men.},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the pharmacokinetics of atenolol (Ate) stereoisomers in Chinese.
METHOD:
A single oral dose of 100 mg of racemic Ate tablets were given to 12 healthy volunteers of Han nationality. Plasma and urine concentrations were determined by the reversed phase HPLC method.
RESULTS:
The disposition of d-Ate and l-Ate was conformed to one-compartment model. Maximal plasma concentration (Cmax): l-Ate (331 +/- 79) micrograms.L-1, d-Ate (342 +/- 78) micrograms.L-1. Area under blood concentration-time curve (AUC): d-Ate (2635 +/- 610) micrograms.h.L-1, l-Ate (2442 +/- 588) micrograms.h.L-1. Renal clearance (Clr): l-Ate (6.9 +/- 1.2) L.h-1, d-Ate (6.5 +/- 1.3) L.h-1.
CONCLUSION:
The disposition of Ate stereoisomers is of stereoselectivity.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7666}
}