@article{APS7664,
author = {Bing ZHU and Guo-Lin CHEN and Xiao-Ping CHEN and Nan HE and Zhao-Qian LIU and Chang-Hong JIANG and Dan WANG and Hong-Hao ZHOU},
title = {Genotype of CYP3AP1 associated with CYP3A activity in Chinese Han population.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM: To investigate the distribution of genotype of CYP3AP1 in Chinese Han
population and the correlation with CYP3A activity.
METHODS: Polymerase chain reaction-restriction fragment length polymorphism
(PCR-RFLP) was employed in CYP3AP1 genotype analysis; using midazolam as probe
drug, CYP3A activity of 191 Chinese healthy subjects was measured by plasma
1'-hydroxymidazolam/midazolam (1'-OH-MDZ/MDZ) ratio at 1 h after oral
administration of 7.5 mg midazolam.
RESULTS: There was significant difference of CYP3A activity in different
genotypes of CYP3AP1 in vivo (P },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7664}
}