@article{APS7636,
author = {Jian-Xun LIU and Xiao-Hong SHANG and Jian-Hua FU and Xin-Zhi LI and Gang WANG},
title = {Effects of recombinant staphylokinase on coronary thrombosis in Chinese experimental miniature swine.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of recombinant staphylokinase (r-Sak) on coronary
thrombosis, cardiac ischemia, and myocardial infarction in Chinese experimental
miniature swine.
METHODS: Endarterium was injuried and coronary thrombi were formed gradually
through direct electrical stimulation on the coronary artery of Chinese
experimental miniature swine. Effects of r-Sak in vitro were studied through
coronary pathological section, microkinematography, multi media graphic analysis,
epicardial electrogram mapping, myocardium histo chemical stain, serum creatine
phosphokinase (CPK), and hemorheology.
RESULTS: r-Sak showed a remarkable effect on coronary thrombus. Compared w ith
the control group, the two dosage groups, r-Sak 0.45 mg/kg and 1.35 mg/kg,
reduced the transverse section area of coronary thrombus (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7636}
}