@article{APS7619,
author = {Jun-qiang Si and Zhi-wang Li},
title = {Inhibition by baclofen of NMDA-activated current in rat dorsal root ganglion neurons},
journal = {Acta Pharmacologica Sinica},
volume = {20},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM:
To explore the modulatory effect of baclofen on NMDA-activated current in rat dorsal root ganglion (DRG) neurons.
METHODS:
Whole-cell patch-clamp technique was used to record NMDA-activated current in isolated DRG neurons. Drugs were applied by rapid solution exchange.
RESULTS:
Preapplication of baclofen 1-100 mumol.L-1 induced a concentration-dependent inhibition of the inward NMDA-activated current markedly. NMDA (100 mumol.L-1)-activated current was inhibited by 52% +/- 14% (n = 11, P < 0.01) by preapplication of baclofen 100 mumol.L-1. The inhibitory effect of baclofen was reversible, and was removed by saclofen 100 mumol.L-1, which was a selective antagonist of GABAB receptor.
CONCLUSION:
Preapplication of baclofen exerts an inhibitory effect on NMDA-activated current in the primary sensory neurons.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7619}
}