@article{APS7600,
author = {Xi-Geng ZHENG and Xin-Wang LI and Xiao-Yan YANG and Nan SUI},
title = {Effects of scopolamine and physostigmine on acquisition of morphine-treated rats in Morris water maze performance.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM: To investigate effects of morphine on acquisition process of rats a nd
interactions of opioid and cholinergic systems by Morris water maze performance.
METHODS: Morris water maze was used to measure the latency of rats with drug s
treatment to find the covert platform.
RESULTS: Chronic morphine administration (10 mg/kg) impaired the acquisition
process of rats in Morris water maze task. Appreciable difference was identified
with morphine 10 mg/k g group compared with morphine 3 mg/kg group.
Co-administration of morphine (10 mg/kg) and scopolamine (3 mg/kg) aggravated
acquisition impairment induced by morphine 1 0 mg/kg or scopolamine alone, though
scopolamine itself induced no salient changes in acquisition capabilities of
rats. In addition, physostigmine (0.1 mg/kg) could appreciably attenuate
morphine-induced acquisition impairment.
CONCLUSION: Morphine 10 mg/kg evidently impaired acquisition process of rats.
There was a close relationship between the acquisition capabilities of
morphine-treated rats and the functions of cholinergic system.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7600}
}