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Effects of 12 beticolins, Cercospora beticola toxins, on proliferation of ras-transformed adrenocortical cell

   
@article{APS7583,
	author = {Guo-Qing Ding and Gabrielle Maume and Hanan Osman and Martine Padieu and Marie-Louise Milat and Claude Humbert and Jean-Pierre Blein and Bernard F Maume},
	title = {Effects of 12 beticolins, Cercospora beticola toxins, on proliferation of ras-transformed adrenocortical cell},
	journal = {Acta Pharmacologica Sinica},
	volume = {22},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {Aim: To explore different effects of 12 beticolins, Cercospora beticola toxins, on ras-transformed adrenocortical cell growth inhibition and their functional mechanism.
Methods: Beticolin-induced inhibition was measured with survival cell number determined by an automated photocolorimetric method. The penetration of beticolin was examined by confocal microscopy. Ras protein determined by Lowry method were separated by 14 % SDS-PAGE and electroblotted to Immobilon-P transfer membrane and detected with pan-Ras (Ab-3) monoclonal antibody. The Ca2+ chelation by beticolin was investigated using a calcium ionophore.
Results: Cell growth inhibition was found dose- and time-dependently at submicromolar level for beticolin-1, -2, and -13 (IC50 },
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7583}
}