@article{APS7548,
author = {Ying-Li Zhang and Shen Yang and Nian-Ci Shi and Ming-Hua Jiang},
title = {Effects of melittin on isolated papillary muscles of guinea pig},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {8},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the effect of melittin (Mel) on papillary muscles of guinea pigs.
Methods: Contraction of papillary muscles were examined by conventional method and action potentials (AP) were recorded by standard glass microelectrode technique.
Results: Mel (0.5, 3 micromol/L) significantly increased the contractility of guinea pig papillary muscles while 5 micromol/L exerted dual action with a transient decrease followed by an increase of the contractility. Mel shortened the functional refractory period (FRP) at concentrations of 0.5, 3, and 5 micromol/L and increased the automaticity induced by adrenaline (Adr) at 3 and 5 micromol/L. Mel shifted the duration-intensity curve upward at 3 micromol/L. It shortened the action potential duration (APD) of fast action potential (FAP), decreased the action potential amplitude (APA) and resting potential (RP) at 0.5 and 3 micromol/L. As to slow action potential (SAP), Mel 0.8 micromol/L shortened APD20 and APD50, and decreased APA and RP.
Conclusion: Mel increased the contractility and automaticity of papillary muscles, shortened the FRP, decreased the excitability, shortened the APD, and decreased APA and RP of AP.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7548}
}