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Dual effects of tetrandrine on calcium-activated potassium channels in pulmonary artery smooth muscle cells

   
@article{APS7539,
	author = {Zhong-feng Wang and Li Kai and Xing-rong Xiao},
	title = {Dual effects of tetrandrine on calcium-activated potassium channels in pulmonary artery smooth muscle cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {20},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the effects of tetrandrine (Tet) on calcium-activated potassium channels.
METHODS:
Inside-out configuration of patch-clamp single channel recording techniques.
RESULTS:
Tet 7.5 and 15 mumol.L-1 increased the open probability from control value 0.251 +/- 0.012 to 0.340 +/- 0.013 and 0.415 +/- 0.011, respectively (P < 0.01), decreased the close time from (61 +/- 15) ms to (33 +/- 10) and (28 +/- 11) ms, respectively (P < 0.01). But Tet 30 mumol.L-1 decreased the open probability and open time to (0.114 +/- 0.008) and (1.47 +/- 0.09) ms, respectively [P < 0.01 vs control (0.251 +/- 0.012) and (20 +/- 8) ms].
CONCLUSION:
Tet has concentration-dependent dual effects on KCa channels in isolated rat pulmonary smooth muscle cells.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7539}
}