@article{APS7444,
author = {Yun-Chun Li and Chang-Tian Guan and Ke-Qing Zhao and Ze-Lian Chen and Tong-Ling Li},
title = {Pharmacokinetics of lactosaminated recombinant human growth hormone in mice},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {5},
year = {2016},
keywords = {},
abstract = {Aim: To study the pharmacokinetic characteristics of lactosaminated recombinant human growth hormone (hGH-L) in mice.
Methods: The biodistribution was studied with in vivo radioactive tracer technique. The pharmacokinetics was investigated by radioimmunoassay (RIA) method of hGH-L. The results were compared with that of recombinant human growth hormone (hGH).
Results: 125I-hGH-L has remarkable livertaxis. The area under drug concentration-time curve (32686.9 microg . min . L-1) in blood and serum mean residence time (21.4 min) of hGH-L are less than that of hGH (36913.1 microg . min . L-1 and 24.9 min) (P < 0.05). In target organ liver, hGH-L distribution half life (1.8 min) and elimination half life (11.1 min) are shorter than that of hGH (2.1 min and 27.7 min) (P < 0.05). The area under drug concentration-time curve (17621.9 microg . min . L-1) of hGH-L is bigger than that of hGH(12148.2 microg . min . L-1) (P < 0.05) in liver.
Conclusion: The pharmacokinetic parameters of hGH-L has obvious advantage over that of hGH.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7444}
}