@article{APS7428,
author = {Hong-Li Shan and Xiao-Dan Zhang and Rui-Min Gu and Da-Li Luo and Bao-Feng Yang},
title = {Effects of erysimin G on renal tubular function and 70-pS K+ channel activity of thick ascending limb},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {5},
year = {2016},
keywords = {},
abstract = {Aim: To study the effect of erysimin G (CH35H52O13) on the thick ascending limb (TAL) 70-pS K+ channel of rat kidney and its effect on diuresis.
Methods: The patch-clamp cell-attached recording technique was used to record the single potassium channel current, and the urine volume (UV) was measured by urethral intubation to determine the diuretic effect.
Results: Erysimin G can increase the urine volume and decrease the 70-pS potassium channel activity of TAL.
Conclusion: Erysimin G has a diuretic effect and its inhibition on the activity of apical 70-pS potassium channel may be the mechanism of its diuretic effect.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7428}
}