@article{APS7371,
author = {Nai-Feng Liu and Zi-Lin Sun and Bi-Cheng Liu},
title = {Clearance of increased serum advanced glycosylation end products in patients with end stage renal disease by hemodialysis},
journal = {Acta Pharmacologica Sinica},
volume = {21},
number = {3},
year = {2016},
keywords = {},
abstract = {\"AIM:
To study the effect of removal of hemodialysis using acetate membrane on serum advanced glycosylation end products (AGEP) in 36 patients (59.1 +/- 1.6) with end stage renal disease (ESRD).
METHODS:
Serum AGEP levels were determined with quantitative fluorescence spectrometry, flow injection analysis (FIA), and competitive enzyme-linked immunosorbent assay (ELISA) using a polyclonal antibody directed against AGEP.
RESULTS:
The serum AGEP levels in patients with ESRD quantified by fluorescence spectrometry, FIA, and ELISA were higher than those in controls [(25 +/- 5) vs (7.5 +/- 1.5), (6.1 +/- 1.8) vs (1.4 +/- 0.5), and (37 +/- 20) vs (9 +/- 10) kU/L, respectively] and markedly reduced to [(22 +/- 6), (4.2 +/- 1.4), and (19 +/- 14) kU/L, respectively] after hemodialysis.
CONCLUSION:
Increased serum AGEP levels in the circulation of patients with ESRD were reduced effectively by hemodialysis.\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7371}
}