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Class III anti-arrhythmia drug E-4031 potentiates Na+/Ca2+ exchange current in rat ventricular myocytes

   
@article{APS7350,
	author = {Dong-Mei Wu and Ji-Yuan Lu and Bo-Wei Wu},
	title = {Class III anti-arrhythmia drug E-4031 potentiates Na+/Ca2+ exchange current in rat ventricular myocytes},
	journal = {Acta Pharmacologica Sinica},
	volume = {21},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {\"AIM:
To study the effects of E-4031 on the Na+/Ca2+ exchange currents (INa/Ca).
METHODS:
The quasi-steady state current-voltage relationship from the isolated rat ventricular myocytes was measured using whole-cell voltage-clamp techniques with a ramp pulse protocol.
RESULTS:
At potential of mV, E-4031 5, 10, and 20 mumol.L-1 increased Ni(2+)-sensitive current from (0.48 +/- 0.12), to (0.78 +/- 0.20), (0.96 +/- 0.16), and (1.15 +/- 0.13) pA/pF, respectively; tetradecanoylphorbol acetate (TPA) 50 nmol.L-1 increased Ni(2+)-sensitive current from (0.60 +/- 0.16) to (1.33 +/- 0.25) pA/pF. Tamoxifen 20 mumol.L-1 completely prevented the current changes induced by E-4031 and TPA.
CONCLUSION:
E-4031 stimulates the Na+/Ca2+ exchange via a protein kinase C-dependent pathway.\"},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7350}
}