@article{APS7294,
author = {Hao Zhang and Jin-wei He and Gao Gao and Hua Yue and Jin-bo Yu and Wei-wei Hu and Jie-mei Gu and Yun-qiu Hu and Miao Li Li and Wen-zhen Fu and Yu-juan Liu and Zhen-lin Zhang},
title = {Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families},
journal = {Acta Pharmacologica Sinica},
volume = {31},
number = {8},
year = {2016},
keywords = {},
abstract = {Aim: To determine the associations between HOXD4 gene polymorphisms with peak bone mineral density (BMD) throughing measuring three tagging single nucleotide polymorphisms (tagSNPs), including rs1867863, rs13418078, and rs4972504, in HOXD4.
Methods: Four hundred Chinese nuclear families with male offspring (1215 subjects) and 401 Chinese nuclear families with female offspring (1260 subjects) were recruited. BMD of the lumbar spine 1-4 (L1-4) and left proximal femur including total hip and femoral neck were measured by dual-energy X-ray absorptiometry. The quantitative transmission disequilibrium test (QTDT) was performed to investigate the association among the tagging SNPs, haplotypes and peak BMD.
Results: Only the CC genotype was identified in rs13418078 in the Chinese population, unlike other populations. We failed to find significant within-family association among these SNPs, haplotypes and peak BMD at any bone site in either male- or female-offspring nuclear families.
Conclusion: The results suggest that genetic polymorphisms in HOXD4 may not be a major contributor to the observed variability in peak BMD in the lumbar spine and the hip in Chinese men and women.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7294}
}