@article{APS7254,
author = {Jia-Qing QIAN},
title = {Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {12},
year = {2016},
keywords = {},
abstract = {Tetrandrine, dauricine, daurisoline and neferine are bisbenzylisoquinoline
alkaloid derivatives isolated from Chinese traditional medicine and herbs. The
cardiovascular pharmacological effects and the mechanism of actions of these
compounds were reviewed. Tetrandrine isolated from Stephania tetrandra S Moore
possesses antihypertensive and antiarrhythmic effects. The antihypertensive
effects of tetrandrine have been demonstrated in experimental hypertensive
animals and in hypertensive patients. Recent studies showed that in addition to
its calcium antagonistic effect, tetrandrine interacted with M receptors.
Modulation by M receptor is one of the pharmacological mechanisms of
cardiovascular effects of tetrandrine. Dauricine and daurisoloine were isolated
from Menispermum dauricum DC. The antiarrhythmic effects of dauricine have been
verified in different experimental arrhythmic models and in cardiac arrhythmic
patients. Dauricine blocked the cardiac transmembrane Na+,K+ and Ca2+ ion
currents. Differing from quinidine and sotalol, which exhibited reverse
use-dependent effect, dauricine prolonged APD in a normal use-dependent manner in
experimental studies. The antiarrhythmic effect of daurisoline and neferine which
is an alkaloid isolated from Nelumbo nucifera Gaertn, and their mechanisms of
actions have also been studied. The antiarrhythmic effect of daurisoline is more
potent than that of dauricine.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7254}
}