@article{APS7246,
author = {Wwi-Min CAI and Jun XU and Bing CHEN and Fu-Min ZHANG and Yuan-Zhu HUANG and Yin-Di ZHANG},
title = {Effect of CYP2D6*10 genotype on propafenone pharmacodynamics in Chinese patients with ventricular arrhythmia.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {11},
year = {2016},
keywords = {},
abstract = {AIM: To determine the effect of CYP2D6*10 genotype on propafenone
pharmacodynamics in Chinese patients with ventricular arrhythmia.
METHODS: Seventeen Chinese patients with ventricular premature contractions (VPC>
or =1000/d) were recruited. They were normal in routine laboratory testing and
administered propafenone hydrochloride 450-600 mg per day in three divided doses.
Twelve lead cardiogram and 24 h Holter monitoring were performed before and after
7 d treatment of propafenone. Steady-state peak and trough concentrations of
propafenone were measured by HPLC method. CYP2D6*10 genotypes of patients were
assayed by polymerase chain reaction (PCR) and restriction fragment length
polymorphism (RFLP).
RESULTS: Total inhibitory rate of VPC was 79.9 % in 17 patients with ventricular
arrhythmia after propafenone treatment. PR interval prolongation was increased
from 0.146 s+/-0.018 s to 0.161 s+/-0.022 s (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7246}
}