@article{APS7244,
author = {Hong-Jie CHEN and Zhi-Ping WANG and Yi-Rong CHEN and Da-Shan QIN and Sheng-Jun FU and Bao-Liang MA},
title = {Effects of pollen extract EA-10, P5 on chronic prostatitis or infertility with chronic prostatitis.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {11},
year = {2016},
keywords = {},
abstract = {AIM: To determine the drug action mechanism of pollen extract EA-10, P5 on the
treatment of chronic prostatitis (CP) or infertility with CP.
METHODS: Malondiadehyde (MDA), superoxide dismutase (SOD), and nitrogen monoxide
(NO) were measured by biochemical assay, and zinc content was assayed by atomical
spectrophotography in the pre-treatment and post-treatment of CP or infertility
with CP.
RESULTS: Compared with control group, leukocytes in expressed protatic secretion
(LEPS), MDA, and NO were increased, and zinc content and SOD were decreased
significantly in the pre-treatment of CP. After the treatment, LEPS was improved,
and MDA and NO were reduced, while zinc content were increased apparently and the
alteration of SOD was not evident (P>0.05). In the pre-treatment of infertility
with CP, LEPS, MDA, NO, sperm viability, and seminal leukocytes were obviously
higher and seminal plasma SOD, zinc content, and sperm motility were obviously
lower than those in control group. After the treatment, LEPS, sperm motility, and
sperm viability were improved, MDA, NO, and seminal leukocytes were decreased,
SOD and zinc content were increased markedly.
CONCLUSION: There was inter-correlation between oxygen free radicals (OFR) and
occurrence, development, and recovery of CP; Change of OFR may be involved in the
drug action mechanism of EA-10, P5 in the treatment of CP or infertility with CP.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7244}
}