@article{APS7224,
author = {Hai-Bo Qiu and Yi Yang and Shao-Xia Zhou and Shao-Hua Liu and Rui-Qiang Zheng},
title = {Prognostic value of dobutamine stress test in patients with septic shock},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {1},
year = {2016},
keywords = {},
abstract = {Aim: To evaluate the prognostic effect of dobutamine stress test in patients with septic shock.
Methods: Patients with septic shock received intravenous infusion of dobutamine at 10 microg . kg-1 . min-1 for 1 h. Hemodynamics and oxygen metabolism was observed. A patient who was able to increase oxygen consumption index (VO2) by >15 % was designated as a responder to the test.
Results: In 47 patients with septic shock, twenty one responders and twenty six nonresponders were identified, and mortality was 33.3 % and 76.9 % respectively. After the dobutamine infusion, the responders showed increases in cardiac index (18.1 %), oxygen delivery index (12.7 %), VO2 (38.6 %), and oxygen extraction ratio (18.0 %), and reductions in systemic vascular resistance index (18.5 %). The nonresponders demonstrated increases in cardiac index (11.5 %), but no change in oxygen delivery, VO2, and oxygen extraction ratio.
Conclusion: Dobutamine stress test might be a good predictor of outcome in patients with septic shock.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7224}
}