@article{APS7211,
author = {Xiao-Song Zhao and De-Zhi Tian and Ying-Jiong Ding and Yi-Chun Zhu and Tai Yao},
title = {Effect of cathepsin B on thymocyte apoptosis in spontaneously hypertensive rats},
journal = {Acta Pharmacologica Sinica},
volume = {22},
number = {1},
year = {2016},
keywords = {},
abstract = {Aim: To further investigate the mechanism of the thymus dysfunction in spontaneously hypertensive rats.
Methods: The location of cathepsin B expression was determined by in situ hybridization. The expression of cathepsin B was analyzed by Northern blot, and thymocyte apoptosis was detected by TUNEL and flow cytometer, respectively.
Results: The expression of cathepsin B in thymus paralleled with thymocyte apoptosis both in vitro and in vivo. Cathepsin B transcripts were located in the plasma of thymocytes and were more over-expressed of 6- and 8-week-old SHR than those in the thymus of WKY.
Conclusion: Thymocyte apoptosis in SHR is increased and this phenomenon is associated with the expression of cathepsin B.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7211}
}