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Stimulation by melittin of Na+-Ca2+ exchange current in ventricular myocytes of guinea pigs

   
@article{APS7205,
	author = {Xue-Mei Zhang and Shen Yang and Yi Zhang and Ping Zheng and Ming-Hua Jiang and Zhao-Nian Zhou},
	title = {Stimulation by melittin of Na+-Ca2+ exchange current in ventricular myocytes of guinea pigs},
	journal = {Acta Pharmacologica Sinica},
	volume = {22},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Aim: To study the mechanism of calcium overload induced by melittin in myocytes. 
Methods: Whole cell patch-clamp technique was applied for recording the currents. 
Results: Mel 0.05, 0.1 micromol/L increased the peak amplitude of I(Na) (nA) from -2.1+/-0.8 to -3.2+/-1.0 (n=7, P < 0.05) and -3.7+/-1.5 (n=7, P < 0.05) respectively at testing potential of -40 mV. Mel 0.05, 0.1, 0.2 micromol/L had no significant effect on I(Ca), but enhanced I(Na-Ca) (pA) from 53+/-21 to 427+/-256 (n=5, P < 0.05), 349+/-147 (n=5, P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7205}
}