@article{APS7190,
author = {Qing-Long GUO and Min-Shu WU and Zhen CHEN},
title = {Comparison of antitumor effect of recombinant L-asparaginase with wild type one in vitro and in vivo.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM: To investigate the antitumor effect of recombinant L-asparaginase on the
growth of several tumors such as P388, L1210, hepatocellular carcinoma (Heps),
K562, P815, and sarcoma 180 (S180).
METHODS: Tumor cells (K562, L1210, and P815) were cultured in vitro and the
morphology of those cells was observed with inverse microscope and transmission
electron microscope. MTT assay was performed to measure the cell proliferation
and inhibition rate. DNA content was assayed by flow cytometry. According to
protocols of transplant tumor research, mice were transplanted with tumor cells
L1210, P388, Heps, and S180. The survival rate and weight of tumor were observed
after the treatment of test drugs.
RESULTS: The antitumor effects of L-asparaginase were observed in vitro with
tumor cells K562, L1210, and P815 (P },
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7190}
}