@article{APS7174,
author = {Tian-De HOU and Ji-Zeng DU},
title = {Beta-endorphin suppresses release of thyrotropin-releasing hormone in rat hypothalamus during acute hypoxia exposure.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {10},
year = {2016},
keywords = {},
abstract = {AIM: To study the influences of beta-endorphin (beta-EP) on the responses of
thyrotropin-releasing hormone (TRH) in median eminence (ME) and paraventricular
nucleus (PVN) of hypothalamus to acute hypoxia in conscious rats.
METHODS: Brain TRH, serum T3 and T4 were measured by radioimmunoassay. The male
Wistar rats were exposed in a simulated hypobaric chamber at 7000 m altitude (8.2
% O2) for 2 h. beta-EP was given by intraventricular injection (icv) before
hypoxia.
RESULTS: beta-EP (0.1 or 1 micromol/L, icv) elevated TRH levels of ME by 12 % (P
},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7174}
}