@article{APS7143,
author = {Hua KANG and Er-Qing WEI and Xiao-Hong YANG and Wei-Ping ZHANG and Jian-Zhong SHEN},
title = {VCAM-1 expression, eosinophil infiltration, and pharmacological modulation in rat allergic airway inflammation.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To determine vascular cell adhesion molecule-1 (VCAM-1) expression and
eosinophil infiltration in the lungs of the rats with allergic airway
inflammation, and their possible modulation by dexamethasone and neurokinin-1
receptor antagonist SR140333.
METHODS: Sensitized rats were challenged with inhalation of 1 % ovalbumin
aerosol. Protein expression of VCAM-1 in the lungs and eosinophil infiltration
around bronchi in different groups were determined 24 h after challenge. SR140333
(0.01 and 0.10 mg/kg) and dexamethasone (0.50 mg/kg) were injected ip, twice a
day, for 3 d before challenge.
RESULTS: The expression of VCAM-1 was increased in the sensitized rat lungs as
compared with the non-sensitized rats (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7143}
}