@article{APS7137,
author = {En-Hui WEI and Man-Ren RAO and Xiu-Ying CHEN and Le-Ming FAN and Qi CHEN},
title = {Inhibitory effects of praeruptorin C on cattle aortic smooth muscle cell proliferation.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of praeruptorin C (pra-C) on proliferation of cattle
aortic smooth muscle cells (SMC).
METHODS: The DNA synthesis of SMC was measured using the incorporation of
[3H]thymidine([3H]TdR). Cell cycle phase was evaluated by flow cytometry and
cytotoxicity was evaluated by measuring lactic dehydrogenase (LDH) activity.
RESULTS: Whether or not treated with angiotensin II (Ang-II), SMC proliferation
was suppressed by pra-C in a concentration-dependent manner at range from 0.001
micromol/L to 10 micromol/L. The inhibitory effects appeared to be related to
G1-S block in cell cycle traverse while the LDH activities did not change
dramatically.
CONCLUSION: Pra-C can completely inhibit SMC proliferation induced by Ang II and
partly inhibit the growth of SMC- induced by bovine serum, which is important in
prevention and treatment of vascular hyperplastic disease.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7137}
}