@article{APS7124,
author = {Zhong CHEN and Ying-Jie SHEN},
title = {Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats.},
journal = {Acta Pharmacologica Sinica},
volume = {23},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To investigate whether or not brain histamine was involved in memory
deficits induced by lesions of nucleus basalis magnocellularis (NBM) in rats.
METHODS: Passive avoidance response was used to measure memory process in rats,
and NBM was bilaterally lesioned by injection of ibotenic acid (6 microg/site).
RESULTS: Icv injection of histamine (500 ng), and ip injection of histidine (1500
mg/kg), metoprine (10 mg/kg) or tacrine (3, 5 mg/kg) ameliorated memory
impairment induced by NBM lesion regarding passive avoidance response. The
ameliorating effect of histidine was antagonized by pyrilamine (2-5 mg/kg), a
H1-antagonist, but not by zolantidine, a H2-antagonist.
CONCLUSION: Histaminergic neurons play an important role in learning and memory
via H1-receptor, and its action may be due to cholinergic neurons.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7124}
}