@article{APS7101,
author = {Yi-Li Xiong and Yue-Hua Zhao},
title = {Effect of captopril on proliferation of aortic smooth muscle cells},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of captopril (Cap) on proliferation of smooth muscle cells (SMC).
METHODS:
Proliferation of cultured porcine aortic SMC was promoted by hyperlipidemic sera (HLS).
RESULTS: Cap (0.2 mg.L-1) remarkably reduced [3H]thymidine ([3H]TdR) incorporation, inhibited DNA synthesis and proliferation of SMC, and lessened morphological changes caused by HLS. After administration of Cap, malondialdehyde (MDA) content and plasminogen activator inhibitor (PAI) activity were reduced, 6-keto-PGF1 alpha and cAMP contents were obviously increased (P < 0.05-0.01).
CONCLUSION: Cap inhibited the proliferation of SMC, associated with MDA, PAI, 6-keto-PGF1 alpha and cAMP.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7101}
}