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Effect of captopril on proliferation of aortic smooth muscle cells

  
@article{APS7101,
	author = {Yi-Li Xiong and Yue-Hua Zhao},
	title = {Effect of captopril on proliferation of aortic smooth muscle cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {17},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of captopril (Cap) on proliferation of smooth muscle cells (SMC).
METHODS: 
Proliferation of cultured porcine aortic SMC was promoted by hyperlipidemic sera (HLS).
RESULTS: Cap (0.2 mg.L-1) remarkably reduced [3H]thymidine ([3H]TdR) incorporation, inhibited DNA synthesis and proliferation of SMC, and lessened morphological changes caused by HLS. After administration of Cap, malondialdehyde (MDA) content and plasminogen activator inhibitor (PAI) activity were reduced, 6-keto-PGF1 alpha and cAMP contents were obviously increased (P < 0.05-0.01).
CONCLUSION: Cap inhibited the proliferation of SMC, associated with MDA, PAI, 6-keto-PGF1 alpha and cAMP.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7101}
}