@article{APS7092,
author = {Sen-qing CHEN and Kai-xian XUE and Jian-zhong WU and Guo-jian MA},
title = {Mutagenic effects of bimolane},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM:
To study the genotoxicity of bimolane.
METHODS:
Bimolane 5, 10, and 15 mg . kg-1 was injected i.p. in mice to investigate its effects on chromosome/chromatid aberrations of bone marrow cells. Mutagenic effects on TA97, TA98, TA100, TA102 were studied in Ames test.
RESULTS:
Bimolane 5, 10, and 15 mg . kg-1 induced of chromosome/chromatid aberrations, and the frequency of aberration cells (ACF) induced by bimolane increased markedly (P < 0.01); Bimolane without S9 showed mutagenic to TA98 and TA102 at the concentrations of 100 and 150 micrograms/plate in Ames test.
CONCLUSION:
Bimolane is a kind of genotoxic compound.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7092}
}