@article{APS7082,
author = {Xiao-ping YANG and Fu-xu WANG and De-cheng REN and Shi-chen LU and Shao-xuan FU and Yun-shan LI},
title = {Effects of 3-morpholinosydnonimine-N-ethylcarbamide on hypoxia-induced mechanical and electric responses of isolated pig coronary artery},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {6},
year = {2016},
keywords = {},
abstract = {AIM:
To study effects of 3-morpholinosydnonimine-N -ethylcarbamide (SIN-1) on hypoxia-induced mechanical and electric activities of the isolated pig coronary artery.
METHODS:
Mechanical tension and membrane potential were measured simultaneously.
RESULTS:
Hypoxia initially caused a transient vascular smooth muscle cell membrane hyperpolarization followed by a membrane depolarization in isolated pig coronary artery. Subsequent addition of SIN-1 100 mumol . L-1 or verapamil (Ver) 10 mumol . L-1 led to membrane repolarization and relaxation of the vascular smooth muscle. Nitro-L-arginine (NLA) 0.2 mmol . L-1 and KCI 40 mmol . L-1 also induced membrane depolarization and vasoconstriction, which were similarly suppressed by SIN-1 or Ver.
CONCLUSION:
Hypoxic contractile response in isolated pig coronary artery is mediated by an increased Ca2+ influx via suppression of nitric oxide release.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7082}
}