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Effects of toquipidine on ionic channels of cultured embryonic Xenopus laevis myoblasts and neurons

   
@article{APS7063,
	author = {Ping ZHENG and Gong CHEN and Nian-ci SHI and Si-ping ZHOU and Ying-qing LU and Ming-hui YAO and Zeng-you HE},
	title = {Effects of toquipidine on ionic channels of cultured embryonic Xenopus laevis myoblasts and neurons},
	journal = {Acta Pharmacologica Sinica},
	volume = {16},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the effects of toquipidine (1-p-methyl-phenyl-2-(alpha-piperidinoacetyl)-1, 2, 3, 4-tetrahydroisoquinoline hydrochloride, Toq), a new anti-arrhythmic agent first synthesized in China, on ionic channels.
METHODS:
Ionic channel currents were recorded by whole-cell patch clamp technique in cultured embryonic Xenopus laevis myoblasts and neurons.
RESULTS:
Toq (0.1, 1, 10, and 100 mumol L-1) caused a concentration-dependent inhibition of the Na+ currents with IC50 7.2 mumol L-1 (5.3-9.8 mumol L-1). Toq (10 mumol L-1) also suppressed the high-voltage-activated Ca2+ currents in neurons. But the steady-state outward K+ currents in myoblasts were activated by Toq (10 mumol L-1).
CONCLUSION:
Toq blocked the Na+ and Ca2+ channels and opened the steady-state outward K+ channels.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7063}
}