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Effects of hemodynamic changes on taurine release from posterior hypothalamus of freely moving rats

   
@article{APS7057,
	author = {Lian-jun GUO and Philippu ATHINEOS},
	title = {Effects of hemodynamic changes on taurine release from posterior hypothalamus of freely moving rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {16},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM:
To study the effects of blood volume and vascular resistance on taurine release.
METHODS:
We used push-pull superfusion technique in the posterior hypothalamus of conscious freely moving rats. Taurine was determined in the superfusate by HPLC with fluorescence detection following automatic precolumn o-phthaldialdehyde (OPA) derivatization.
RESULTS:
Hypervolemia increased the release of taurine in the hypothalamus. Intravenous infusion of levarterenol (3 micrograms kg-1 min-1) elicited a pronounced pressor response and an increase in the release of taurine. Conversely, a controlled hemorrhagic hypotension or iv infusion of nitroprusside (30 micrograms kg-1 min-1) elicited a hypotension and a decrease in the release of taurine from the posterior hypothalamus.
CONCLUSION:
In the posterior hypothalamus, taurine might play an important role in central blood pressure regulation.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/7057}
}