@article{APS7054,
author = {Bo-chu QIAN and Ming WANG and Zhi-fang ZHOU and Kai CHEN and Rong-rong ZHOU and Guo-shen CHEN},
title = {Pharmacokinetics of tablet huperzine A in six volunteers},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM:
To study pharmacokinetics of tablet huperzine A (Hup-A) in Chinese volunteers to help establishing its drug administration schedule.
METHODS:
For 6 volunteers after a single oral dose of 0.99 mg, drug concentrations in plasma were assayed by reverse phase high pressure liquid chromatography (HPLC) at 0.5, 0.75, 1.0, 1.25, 1.5, 2, 4, 6, 8, and 10 h. The pharmacokinetic parameters were calculated with a 3P87 program by computer.
RESULTS:
The time course of plasma concentrations conformed to a one-compartment open model with a first order absorption. The pharmacokinetic parameters were as follows: T 1/2ka = 12.6 min, T 1/2ke = 288.5 min, Tmax = 79.6 min, Cmax = 8.4 micrograms L-1, AUC = 4.1 mg L-1 min.
CONCLUSION:
Hup-A was absorbed rapidly, distributed widely in the body, and eliminated at a moderate rate.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7054}
}