@article{APS7038,
author = {Xia YIN and Yan-hua ZHU and Deng-kai HUANG and Shao-fen XU},
title = {Different distributions of opioid receptors in spontaneously hypertensive rats and Wistar-Kyoto rats},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM:
To compare the densities of opioid receptors in spontaneously hypertensive rats (SHR) with those of normotensive Wistar-Kyoto (WKY) rats in central nervous system which are related to the regulation of BP.
METHODS:
[3H] Etorphine, a nonspecific opioid ligand, was used to determine the distributions of opioid receptors in 16-wk-old SHR and WKY rats by quantitative autoradiography.
RESULTS:
The densities of [3H]etorphine in hippocampus (P < 0.01), periaqueductal gray, nucleus of the solitary tract, and thoracic (T4-6) spinal cord (P < 0.05) of SHR were lower than those of WKY rats. But in basolateral amygdaloid nucleus (P < 0.01), habenular nuclei (P < 0.05), and hypothalamic nuclei including arcuate nucleus (P < 0.01), higher densities of opioid receptors were found in SHR. No difference existed in interpeduncular nuclei between the 2 groups.
CONCLUSION:
The difference in distributions of opioid receptors is related to the hypertension in SHR.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/7038}
}