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Somatostatin and electroacupuncture inhibited c-fos expression in spinal cord of arthritic rats

  
@article{APS6983,
	author = {Huai-Zhen Ruan and Xi-Cheng Li and Hai-Di Li and Bang-Yun Zhao},
	title = {Somatostatin and electroacupuncture inhibited c-fos expression in spinal cord of arthritic rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To observer the effect of intrathecal injection of somatostatin (Som)
associated with electroacupuncture (EA) at \"\"Jiaji\"\" points on c-fos protein
expression of spinal cord in pain rats.
METHODS: Rats with adjuvant arthritis were used as pain model and the c-fos-like 
immunoreactivity (FLI) was detected by immunohistochemistry.
RESULTS: The c-fos protein expression induced by arthritis were found in all of
the I-X laminae of ipsilateral spinal cord of rats, and most of the labeled cells
were located in the laminae I-II and V-VI. Som and EA suppressed the c-fos
expression and the lessening of FLI cells in the spinal cord.
CONCLUSION: Pathological pain following arthritis activated pain sensitive
neurons (PSN) and evoked c-fos expression in spinal cord, Som and EA suppressed
activities of these PSN, producing the effect of analgesia.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6983}
}