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Effects of low-molecular-weight Rehmannia glutinosa polysaccharides on p53 gene expression

   
@article{APS6981,
	author = {Xiao-Long Wei and Xiang-Bin Ru},
	title = {Effects of low-molecular-weight Rehmannia glutinosa polysaccharides on p53 gene  expression},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study the effect of low-molecular-weight Rehmannia glutinosa
polysaccharides (LRPS) on p53 gene expression.
METHODS: The level of p53 gene expression was determined by quantitative
polymerase chain reaction and autoradiography.
RESULTS: The levels of p53 mRNA in Lewis lung cancer tissue were 0.46, 1.52,
1.48, and 1.60 respectively after saline, LRPS 20 and 40 mg.kg-1, and
cyclophosphamide 10 mg.kg-1, which were the effective doses inhibiting the growth
of tumor tissue cells in vivo. LRPS markedly increased p53 gene expression.
CONCLUSION: LRPS effect on p53 gene expression is one of the mechanisms of
antitumor activity.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6981}
}