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Modulation of multidrug resistance by three bisbenzyl-isoquinolines in comparison with verapamil

  
@article{APS6976,
	author = {Hui Tian and Oi-Chao Pan},
	title = {Modulation of multidrug resistance by three bisbenzyl-isoquinolines in comparison with verapamil},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {AIM: To compare cycleanine (Cyc), insularine (Insr), insulanoline (Insn) and
verapamil (Ver) in modulation of multidrug resistance (MDR) in vitro.
METHODS: The cytotoxic effect was determined by 3-[4, 5-dimethylthiazol-2-yl],
5-diphenyl tetarzolium bromide (MTT) assay. The intracellular doxorubincin (Dox) 
accumulation was assayed by spectrofluorometer.
RESULTS: Cyc, Insr, Insn, and Ver showed significant activities in modulating Dox
and vincristine resistances in acquired resistant MCF-7/Adr and KBv200 cell lines
in a dose-dependent manner. Cyc, Insr, Insn, and Ver increased intracellular Dox 
accumulation in MCF-7/Adr cells. Cyc and Insr had greater activities than Ver in 
modulating MDR, while Insn had similar activity to that of Ver.
CONCLUSION: MDR was modulated by Cyc, Insr, and Insn, due to the increase of
intracellular Dox accumulation.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6976}
}