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Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum

   
@article{APS6949,
	author = {Jian-Tu Che and Jun-Tian Zhang and Zhi-Wei Qu and Guo Wei},
	title = {Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in
cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels.
METHODS: Northern and dot blotting, dual wavelength thin layer chromatography
scanner, were used in this study.
RESULTS: Lindane 30 mg.kg-1 given by intragastric gavage (i.g.) increased the
expression of c-fos gene to 146 mm2 in rat cerebrum 1 h after treatment. Tet 1,
2, and 4 mg.kg-1 given by i.g. 30 min prior to lindane reduced c-fos gene
expression in a concentration-dependent manner. Expressed genes reached only 86, 
40, and 39 mm2, respectively.
CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+
agonist-lindane.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6949}
}